M. Falret knew the case of a man who always felt disposed to cut his throat when under the influence of spirits. No reasoning could induce him to abstain from his favourite draught. The inevitable consequences were pointed out to him; he was reasoned with, and threatened with confinement in a mad-house; but nothing had the desired effect. One Sunday evening, after having drunk several glasses of spirits, although not sufficient to produce complete inebriation, he stabbed himself to the heart, and died in a few minutes. Incurable indigestion and organic disease of the liver are very commonly met with in habitual drunkards. In such persons, the constitution of the mind appears to undergo a complete change. At first it may not be perceptible, and the patient may not be conscious of it himself, but the mental disease will, sooner or later, unequivocally evince itself. In such cases, the medical man has fearful odds to contend against. A young man, who had become insane in consequence of long continued intoxication, made violent efforts to maim himself, and especially to pull out his right eye, which appeared to give him great offence. Rest, temperance, seclusion, the application of half a dozen leeches to the temple, and a few doses of opening medicine, restored him, in about a fortnight, to the full possession of his faculties. Many cases of suicide, in those who have a natural predisposition to it, arise from the brain sympathizing with the liver; nor can this be a matter of surprise to any one who has felt the depression of spirits incident to disease of that organ. So many cases have occurred from this cause, that some writers, from not finding, on subsequent dissection, any organic lesion of the brain, have referred it to diseased viscera only. But as we find that the insanity ceases when the liver is restored to health, there is no reason for supposing that the mental alienation is, in these instances, any other than the effect of disease of the brain.