With very few exceptions, the mental symptoms are those which are principally manifested in these cases. Lowness of spirits, a love of solitude, an indisposition to follow any occupation which requires exercise of the mind, are generally exhibited. The person’s suspicions become roused; he fancies his dearest friends are regardless of his interests, or are plotting against his life. He takes no pleasure in the family circle. He may be suffering from some evident physical malady, acting through sympathy on the brain, and deranging its functions; and then he will often refer to his disease, and express his utter hopelessness of ever being cured. There is an expression of countenance generally present in a person who meditates suicide, which, if once seen, cannot easily be forgotten. Suicidal mania is easily recognised by the experienced physician. The surgeon of a large establishment in the environs of the metropolis informed me, that in six cases out of ten he could detect, by the appearance of the eye, the existence of the desire to commit self-destruction. A young gentleman, a few days previously, had been admitted into the house as a patient. The surgeon, after examining and prescribing for the lunatic, said to one of the keepers, “You must watch Mr. —— carefully, for I feel assured he will attempt his life.” Everything with which he might injure himself, were he so disposed, was taken from him; but it appears that he had resolved to make away with himself, and had carefully concealed a penknife in his boot. On the evening of the day on which he was admitted he made a dreadful gash in his throat, but failed in injuring any large vessel. He confessed that he had determined to sacrifice his life; he said, “It has been pre-ordained that I should fall by my own hands, and I am only fulfilling my destiny by cutting my throat!” Shortly after this he was removed; and as we have been subsequently informed, sufficient care not being taken of him, he eventually succeeded in killing himself.