_M. Gase_, in a memoir read before the _Academie Royale de Médecine_, traces the increase of suicide in Paris to the spirit of gambling which the Parisians so passionately indulge in. The extended system of speculation in this country approximates in its pernicious effects on the constitution to those which have been considered to result from gambling. The following case, which was communicated to a popular journal, by Dr. J. Johnson, forcibly illustrates how the constitution may be undermined by rash, inconsiderate conduct, during the excitement arising from temporary circumstances:— One day, on the Stock Exchange, when the rumours of failings at home and commotions abroad were producing such alarming vacillations in the public funds that the whole property of a gentleman of high probity, temperance, and respectability, was in momentary jeopardy, he found himself in so terrible a state of nervous agitation that he was obliged to leave the scene of confusion, and apply to wine, though quite unaccustomed to more than a glass or two after dinner. To his utmost surprise, the wine had no apparent effect, though he drank glass after glass, in rapid succession, until he had finished a whole bottle. Not the slightest inebriating influence was induced by this unusual quantity taken before dinner. His nervous agitation was, however, calmed, and he went back to the Exchange, and transacted business with steadiness, composure, and equanimity. None of the ordinary effects of wine were produced at the time, but a few days afterwards he was seized with a severe attack of indigestion, a malady by which he had never been previously affected. This case shews that although mental agitation masks, or even prevents, the usual effects of wine, and other stimulants, at the time, and thus enables, and indeed induces, men to take more than under ordinary circumstances, yet the ulterior effects are greatly worse on the constitution than if the stimulants had produced the usual excitement at the moment of their reception into the stomach. It is thus, we have no doubt, that the nervous system of thousands in this country is ruined, and, in numerous cases, the seeds of suicidal derangement sown, and that without the victims being conscious of the channel through which they have been poisoned.