In the year 1848, Pastor Dzierzon lost a large number of stocks from this disease; he, however, was enabled to banish it from his apiary, and communicated to a German bee-journal very wholesome advice, which Mr. Langstroth quotes, and from which we make an extract:--"When the malady makes its appearance in only two or three of the colonies, and is discovered early (which may readily be done in hives having movable combs), it can be arrested and cured without damage or diminution of profit. _To prevent the disease from spreading in a colony, there is no more reliable and efficient process_ THAN TO STOP THE PRODUCTION OF BROOD; for where no brood exists, none can perish or putrefy. The disease is thus deprived both of its aliment and its subjects. The healthy brood will mature and emerge in due time, and the putrid matter remaining in a few cells will dry up and be removed by the workers. All this will certainly result _from a well-timed removal of the queen_ from such colonies. If such removal becomes necessary in the spring or early part of the summer, a supernumerary queen is thereby obtained, by means of which an artificial colony may be started, which will certainly be healthy if the bees and brood used be taken from healthy colonies. Should the removal be made in the latter part of summer, the useless production of brood will at once be stopped and an unnecessary consumption of honey prevented. Thus, in either case, we are gainers by the operation." In cases where the disease assumes a more malignant character--in other words, "has got ahead," through "not being nipped in the bud,"--it will be well to take notice of another quotation from Mr. Langstroth's book:--"In the spring or summer, when the weather is fine and pasturage abounds, the following cure is recommended by a German apiarian:--'Drive out the bees into any clean, hive, and shut them up in a dark place without food for twenty-four hours; prepare for them a clean hive, properly fitted up with comb from healthy colonies; transfer the bees into it, and confine them two days longer, feeding them with pure honey.'"