Thus much on avoiding unhealthy, irritable states. But it still remains that a large number of people will be subject to them unavoidably for these reasons. _First._ The use of tobacco, alcohol, and other kindred stimulants, for so many generations, has vitiated the brain and nervous system, so that it is not what it was in former times. Michelet treats of this subject quite at large in some of his late works; and we have to face the fact of a generation born with an impaired nervous organization, who will need constant care and wisdom to avoid unhealthy, morbid irritation. There is a temperament called the HYPOCHONDRIAC, to which many persons, some of them the brightest, the most interesting, the most gifted, are born heirs,--a want of balance of the nervous powers, which tends constantly to periods of high excitement and of consequent depression,--an unfortunate inheritance for the possessor, though accompanied often with the greatest talents. Sometimes, too, it is the unfortunate lot of those who have not talents, who bear its burdens and its anguish without its rewards. People of this temperament are subject to fits of gloom and despondency, of nervous irritability and suffering, which darken the aspect of the whole world to them, which present lying reports of their friends, of themselves, of the circumstances of their life, and of all with which they have to do. Now the highest philosophy for persons thus afflicted is to understand themselves and their tendencies, to know that these fits of gloom and depression are just as much a form of disease as a fever or a toothache, to know that it is the peculiarity of the disease to fill the mind with wretched illusions, to make them seem miserable and unlovely to themselves, to make their nearest friends seem unjust and unkind, to make all events appear to be going wrong and tending to destruction and ruin. The evils and burdens of such a temperament are half removed when a man once knows that he has it and recognizes it for a disease, when he does not trust himself to speak and act in those bitter hours as if there were any truth in what he thinks and feels and sees. He who has not attained to this wisdom overwhelms his friends and his family with the waters of bitterness; he stings with unjust accusations, and makes his fireside dreadful with fancies which are real to him, but false as the ravings of fever. A sensible person, thus diseased, who has found out what ails him, will shut his mouth resolutely, not to give utterance to the dark thoughts that infest his soul.