The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic DevelopmentHertwig, Oscar
Science
The Biological Problem of To-day: Preformation Or Epigenesis?: The Basis of a Theory of Organic Development
Hertwig, Oscar
Developmental biology; Embryology; Genetics
Now, let one reflect that the egg and the adult are two terminal states of
organised material, and that they are separated from each other by an
almost inconceivably long series of connecting, intermediate states;
consider that each stage of the development is the rudiment and the
producer of the succeeding stage, of the stage that follows, as the
consequence of it; consider that what was external in each antecedent stage
has entered the rudiment and become part of it in the succeeding stage.
Then it will be understood that it is a logical error to assume that all
the characters present in the last link of the chain of development have
their determining causes in the first link of the chain. The mistake lies
in this: in the failure to distinguish between the causes contained in the
egg at the beginning of the development, and the causes entering it during
the course of development from the accession of external material in the
various stages. As there can be no absolute identity between rudiment and
product, it is erroneous to transmute the visible complexity of the final
stage of the development into an invisible complexity of the first stage,
as the old evolutionists did, and as the new evolutionists are attempting
to do.
But there is another error in the doctrine of determinants. This is in
intimate union with the error just discussed, and, to put it shortly,
consists in attributing to a cell--and the egg and spermatozoon are
cells--the possession of characters not peculiar to cells, but resulting
from the co-operation of many cells.
The characters of an adult active organism, like a plant or an animal, are
exceedingly numerous, most varied in their nature, and essentially
different. Some characters depend upon the healthy co-operation of nearly
all the parts of the body, or of a group of organs; others are peculiar to
an organ, and may be referred to its shape, structure, position, function,
and so forth. Others, again, depend upon individual cells, or even upon
separate parts of cells. Is it really possible that all these characters,
so many and so heterogeneous, have special, material bearers in the germ,
and that these bearers are either simple biophores or determinants--that is
to say, groups of biophores?
I can conceive a cell as endowed only with the material bearers of such
characters as really belong to a cell itself. Thus, a reproductive cell
might have material particles as the rudiments for producing horn, chitin,
chondrin, ossein, pigment, or chlorophyll, or for nerve-fibrils,
muscle-fibrils; but not for producing a hair, or a separate ganglion of the
spinal cord or the biceps muscle. The rudiments for hairs, nerve-ganglia,
muscles, and so forth, must be groups of cells, for only groups of cells,
and not specially arranged groups of particles within a cell, are able to
grow into hairs, spinal ganglia, or muscles.
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