Without attributing more to deception and fraud than to the peculiar nature of a progressive mental malady, it may readily be conceived that the cases of this strange disorder now grew more frequent. The celebrated Matthioli, who is worthy of entire confidence, gives his account as an eye-witness. He saw the same extraordinary effects produced by music as Alexandro, for, however tortured with pain, however hopeless of relief the patients appeared, as they lay stretched on the couch of sickness, at the very first sounds of those melodies which made an impression on them--but this was the case only with the tarantellas composed expressly for the purpose--they sprang up as if inspired with new life and spirit, and, unmindful of their disorder, began to move in measured gestures, dancing for hour together without fatigue, until, covered with a kindly perspiration, they felt a salutary degree of lassitude, which relieved them for a time at least, perhaps even for a whole year, from their defection and oppressive feeling of general indisposition. Alexandro's experience of the injurious effects resulting from a sudden cessation of the music was generally confirmed by Matthioli. If the clarinets and drums ceased for a single moment, which, as the most skilful payers were tired out by the patients, could not but happen occasionally, they suffered their limbs to fall listless, again sank exhausted to the ground, and could find no solace but in a renewal of the dance. On this account care was taken to continue the music until exhaustion was produced; for it was better to pay a few extra musicians, who might relieve each other, than to permit the patient, in the midst of this curative exercise, to relapse into so deplorable a state of suffering. The attack consequent upon the bite of the tarantula, Matthioli describes as varying much in its manner. Some became morbidly exhilarated, so that they remained for a long while without sleep, laughing, dancing, and singing in a state of the greatest excitement. Others, on the contrary, were drowsy. The generality felt nausea and suffered from vomiting, and some had constant tremors. Complete mania was no uncommon occurrence, not to mention the usual dejection of spirits and other subordinate symptoms. SECT. 4--IDIOSYNCRASIES--MUSIC Unaccountable emotions, strange desires, and morbid sensual irritations of all kinds, were as prevalent as in the St. Vitus's dance and similar great nervous maladies. So late as the sixteenth century patients were seen armed with glittering swords which, during the attack, they brandished with wild gestures, as if they were going to engage in a fencing match. Even women scorned all female delicacy, and, adopting this impassioned demeanour, did the same; and this phenomenon, as well as the excitement which the tarantula dancers felt at the sight of anything with metallic lustre, was quite common up to the period when, in modern times, the disease disappeared.