Extracts from “A Boke or Counseill against the Disease commonly called the Sweate or Sweatyng Sicknesse,” made by John Caius, Doctour in Phisicke.-- Emprinted at London. A. D. 1552. “Hetherto I haue shewed the beginning, name, nature & signes of this disease: now I will declare the causes, which be ii: infection, & impure spirites in bodies corrupt by repletion. Infection, by th’aire receiuing euel qualities, distempring not only y^e hete, but the hole substance thereof, in putrifieng the same, & that generally ii waies. By the time of the yere vnnatural, and by the nature and site of the soile & region . whereunto maye be put the particular accidentes of this same. By the time of the yeare vnnaturall, as if winter be hot & drie, somer hot & moist (a fit time for sweates) the spring colde and drye, the fall hot & moist. To this mai be ioyned the euel disposition by constellation, whiche hath a great power & dominion in al erthly thinges. By the site & nature of the soile & region, many wayes. First and specially, by euel mistes & exhalations drawen out of the grounde by the sunne in the heate of the yeare, as chanced among the Grekes in the siege of Troy, whereby died firste dogges & mules, after, men in great numbre: & here also in England in this M.D.L.I. yeare, the cause of this pestilent sweate, but of dyuers nature. Whiche miste in the countrie wher it began, was sene flie from toune to toune, with suche a stincke in morninges & euenings, that men could scarcely abide it. Then by dampes out of the earth, as out of Galenes Barathrum, or the poetes auernum, or aornum, the dampes wherof be such, that thei kil y^e birdes flieng ouer them. Of like dampes, I heard in the north country in cole pits, wherby the laboring men be streight killed, except before the houre of coming therof (which thei know by y^e flame of their candle) thei auoid the ground. Thirdly by putrefaction or rot in groundes aftre great flouddes, in carions & in dead men. After great fluddes, as happened in y^e time of Gallien the Emperor at Rome, in Achaia & Libia, wher the seas sodeinly did ouerflow y^e cities nigh to y^e same. And in the XI yeare of Pelagius, when al the flouddes throughe al Italye didde rage, but chieflye Tibris at Rome, whiche in many places was as highe as the walles of the citie.