The Body at Work: A Treatise on the Principles of PhysiologyHill, Alex
Science
The Body at Work: A Treatise on the Principles of Physiology
Hill, Alex
Physiology
Much thought has been devoted to the question of the form in which
fat is absorbed. Fat in the chemical sense—a pure fat, that is to
say—is a compound of a fatty acid and glycerin. Suet, lard, butter,
vegetable oils, etc., are mixtures of several fats. All consist of
glycerin united with fatty acids. The acids are stearic acid, palmitic
acid, oleic acid, and others of less importance. Fats are insoluble
in water; so also are the fatty acids. A fatty acid combined with an
alkali (in place of glycerin) is a soap. Soaps are soluble in water.
If milk is examined under the microscope, it is found to contain
droplets of fat, varying in size, but all minute. The larger droplets
tend to rise to the surface as cream, but the smaller droplets do
not run together. If milk from which the cream has been skimmed
is sterilized, it retains its normal appearance for an indefinite
time. Its fat remains in droplets. In technical language, milk is an
emulsion. Theoretically oil and water would make an emulsion, if the
droplets of oil were rendered sufficiently minute. Such a condition
has been almost obtained by agitating oil and water with powdered
glass. But the more viscous the medium through which oil globules
are distributed, the greater is the resistance to their fusion. If
oil which has become rancid—in which a certain quantity of fatty
acid has been liberated from the glycerin with which, in a neutral
fat, it is combined—is shaken with water containing carbonate of
soda, an emulsion is easily formed. The carbonate of soda and the
fatty acids form soaps. A solution of soap is sufficiently viscous to
keep the droplets of oil apart. Emulsification of fats occurs in the
intestine. It might be assumed that the epithelial cells ingest fat
in this finely divided state. But it must be remembered that, however
minute the droplets, they are enormously large as compared with the
molecules of peptones and sugar which the epithelial cells absorb.
It is unlikely that fat is absorbed in a manner so widely different
from that in which other foods enter the epithelial cells. Nor is
it necessary to make any such assumption. Pancreatic juice contains
a ferment which rapidly splits fats into their constituent fatty
acids and glycerin. In the presence of an alkali the fatty acids are
converted into soaps. In this soluble condition of soap and glycerin
the fats are probably absorbed. As soon as they have entered the cell,
the fatty acids and glycerin reunite to form fats, setting the alkali
free. The alkali is returned to the intestine, where it is available as
a solvent of further droplets of fat. The droplets of fat accumulate
in the epithelial cells. During active digestion they are also to be
seen in the connective-tissue cells, in the leucocytes, and in the
lymph inside the lacteal vessel. The epithelial cells extrude the oil
droplets, backwards, much in the same way as the cells of the mammary
glands extrude globules of milk. In herbivora, and in Man also so far
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