The Body at Work: A Treatise on the Principles of PhysiologyHill, Alex
Science
The Body at Work: A Treatise on the Principles of Physiology
Hill, Alex
Physiology
this is written “10 volumes per cent.” To ascertain experimentally
the tension of a particular gas in a particular fluid when dissolved
to the amount of 10 volumes per cent. at the ordinary pressure of the
atmosphere and at the temperature of the body, it would be necessary
to place it in an open vessel in air containing a sufficient admixture
of the gas to prevent its escape from the fluid. Suppose that it were
found that, when the fluid containing the dissolved gas was placed in
air mixed with the same gas to the extent of one-tenth of its volume,
the fluid neither gave up gas nor absorbed more gas, the tension
of the gas would be equal to one-tenth of an atmosphere. Since the
pressure of the atmosphere equals 760 millimetres of mercury, the
tension of the dissolved gas would be 76 millimetres. If more gas were
added to the air, more would dissolve in the fluid; if some of the
gas were removed from the air, gas would escape from the fluid. Gas
passes from the medium in which its tension is high to the medium in
which its tension is low. The tension of carbonic acid in tissues,
particularly in muscles and glands, is higher than in lymph; in lymph
higher than in blood; in blood higher than in air. Hence it passes by
these several stages from the tissues in which it is formed to the air
in the lungs. Much ingenuity has been devoted to perfecting methods
for the determination of the tension of carbonic acid in lymph and
in venous blood. Frequently results have been obtained which seemed
opposed to the doctrine that carbonic acid progresses from one medium
to another in accordance with the law of pressures; but such perplexing
results were probably due either to imperfections in method or to the
establishment of abnormal physiological conditions during the course
of the observations. When, for example, it was found that the tension
in lymph was less than the tension in blood, the specimen of lymph
examined was probably not in the same condition as the lymph in the
tissue-spaces where the exchange occurs. The experimenter in such
a case was in error in supposing that the specimen of lymph which
he examined contained as much carbonic acid as did the lymph in the
tissue-spaces from which the blood which he compared with it received
its supply of this gas.
We have already given the figures for the composition of the air in the
air-chambers of the lungs. The figures commonly accepted as correct for
the percentages of the several gases in the blood are, at 0° C. and 760
millimetres of mercury pressure:
Carbonic
Oxygen. anhydride. Nitrogen.
In 100 vol. of arterial blood 20 39 1-2
In 100 vol. of venous blood 8-12 46 1-2
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