The six inquisitors were empowered to take such measures as they found necessary, with or without the co-operation of the local bishops, for the detection and punishment of heretics, the examination of suspected persons, the destruction of pernicious literature, and generally for the suppression of heresy. They were also to appoint delegates or sub-inquisitors, and to take action on appeals from all the lower tribunals of the Inquisition. In 1558, Paul IV ordered that the inquisitor-general or chief should always be a cardinal, and that he should be charged with the supervision of all matters of faith, proceedings against heretics, etc. He was to retain this special authority during any vacancy in the Papacy. The Cardinal of Alexandria, Ghislieri, was, however, the only one who held this sole authority. When, in 1566, he was chosen Pope as Pius V, he appointed four cardinals as inquisitors-general. Lea points out that the purpose of the institution of the Inquisition was not merely the suppression of heresy, but the reform of corruption and the correction of the immoralities that had sprung up within the Church. Lea is speaking more directly of the Inquisition in Spain, but the statement apparently holds good also for the Inquisition of Rome, which charged itself later particularly with the work of carrying out the reforms ordered by the Council of Trent. _1543._ _The Inquisitors-general_ issue an edict for the suppression of heretical literature and of books written by heretics. The book-dealers throughout Italy are forbidden, under penalty of excommunication and of a fine of 1000 ducats, and of other punishments to be determined in the several cases, to sell or to possess any books written by heretics, or tainted with heresies. They are further ordered to place in readiness for inspection all books then in stock or later received, and thereafter to sell no books that have not been examined and approved by inspectors appointed for the purpose. Similar instructions are issued for the printers concerning the printing of books condemned. The inquisitor of Ferrara and Bologna is delegated to arrange for the inspection of printing-offices, bookshops, libraries, convents, churches, and private houses, and to make destruction of all books to be classed as heretical, and to report the names of all printers, dealers, librarians, or others who refuse or evade co-operation in such search.