During the first three fourths of the 16th century, the Netherlands, with Antwerp as a centre, present the type of a most enlightened community. At the time of the great siege of 1585, Antwerp was at the height of its prosperity, and in the extent and the varied character of its commercial relations it was possibly the leading city of Europe. Antwerp possessed exceptional advantages as a centre of book-production and by the close of the 16th century, out of the sixty-five printers who were at work in the Netherlands, no less than thirteen were in Antwerp. The neighbouring University of Louvain supplied scholarly coöperation which was essential for all the publishing undertakings of the age, while not a few scholars, who, some years later, found themselves with the exiles in Leyden or in Amsterdam, were at this time resident in Antwerp, and were already largely associated with the work of the printing-press. In 1556, at the time of the beginning of the work of the great publisher Plantin, an entire quarter of the city was devoted to the making of books, a circumstance without a parallel among the cities of Europe. The result of the censorship of the Spanish Government was practically to crush out the book business of Antwerp. The presses were largely destroyed and the scholars and printers alike were scattered among the towns of Holland. Plantin placed his imprint upon a number of books of theology, for all of which it was necessary to secure the approval, with the “royal privilege,” of the Duke of Alva and of the successors of the Duke who represented the Spanish Throne. [Sidenote: Book Regulations, 1560–1570] The ordinances issued by Philip II concerning books were for the most part merely a confirmation, with some increase in severity, of the edicts of Charles V. The modifications in these ordinances brought about by the States-General in 1566 provided that those books only should be prohibited that contained heretical or pernicious opinions; and that the responsibility for the examination and decision should be shared with the theologians by the scholars of the other university faculties; that instructors should be at liberty to utilise all books not on the prohibited lists; and that the visitation to the bookshops should be made only under the direct authority of the magistrates. Under Alva, the routine for such a visitation was to instruct the magistrates on a specific day (not announced in advance) to place seals on the doors of all printing-offices and bookshops; the examination of the books was then carried out by the suffragan bishop and the local head of the Franciscans. In the years 1566 and 1567, four printers were sentenced to banishment for from four to six years, one was sent to the galleys, and one was hanged.[147]