That condition can be secured and maintained in an organism that itself is constantly decaying in all of its tissues and organs only by strict compliance with the natural laws governing the operations of the body as an independent organism in which all of its forces tend to promote its health and conservation. Every tissue and every organ has its special means of renewal of its tissue by the removal of dead particles through the outlets and the reception of fresh material through the inlets of the body. Waste and supply are exactly balanced, as in the most precise and delicate machine. If the outlets become clogged, so that all the waste cannot escape at that proper time, dead matter, the food of bacteria, begins to accumulate, and disease must result. In the same manner, if the food is in excess of the demands, or of a quality not suited to the needs of the tissue or organ, waste begins to accumulate, bacteria swarm in the decomposing mass, and emit their toxins, which, absorbed into the circulation, cause a variety of physical disturbances according to the species of bacteria present, and the particular tissues the toxins affect, as the nervous system, stomach, heart, kidneys, etc. That even the most feeble minded may be able to regulate their habits so as to secure an adequate supply of food both in quality and quantity, and the prompt removal of waste matter, so as to secure that degree of cleanliness of internal organs essential to escape from bacterial attacks, the mechanism of the body is endowed with instincts that make it automatic in its action. Such are appetite and taste for food and drinks; the desire for exercise, rest, and sleep; the impulse of the organs in an active state, etc. It is only when these natural monitors are interfered with that the mechanism begins to fail in its elimination of waste, and bacteria find the conditions favorable for their functional activity. [Sidenote: Destroy the Bacteria] The second defensive measure is the destruction of the bacteria by means of agents that will destroy the microörganism before or after its entrance into the body, but without injuring the healthy tissues. There is a great variety of these agents of more or less power, and they are used in the form of gases, liquids, and powders, according to conditions existing in individual cases. In general, it may be advised that, as bacteria are everywhere, germicides ought to be used far more extensively than they are for the purposes of securing not only the direct destruction of bacteria, but of removing or neutralizing dead matter, the food of bacteria. So minute are bacteria, and so adherent are they to material things, that mere bathing with water does not remove them, medicate it as we may with fancy soaps. There should be used in addition a more penetrating and destructive agent, which would not only destroy all forms of bacteria, but at the same time secure absolute cleanliness. [Sidenote: The Value of Germicides]