This act created enmity between the Farnesi and the emperor, though Paul III. had furnished the latter with men and money for his war against the Duke of Saxony, sending twelve thousand horse under the command of Ottavio Farnese and Alessandro Vitelli. But the increasing greatness of Charles, throwing into the shade the prerogatives and power of the Papal See, the disappointed hope of a principality and the league of the emperor with England the enemy of the Papacy, rendered Paul a bitter foe of Spain and awakened in him the ambition to crush the imperial power. Andrea Doria hated the Farnese not less cordially than Charles. He had opposed the advancement of this family for ten years, and had frustrated a proposed league between the Papal See and the empire. He had influenced Charles to refuse the duchy of Milan to Pierluigi, and subsequently to deny Ottavio, son of Pierluigi, the government of Tuscany according to a promise the emperor had made when Ottavio married his illegitimate daughter Margaret, of Austria. Doria urged against the last scheme that if the Farnese were made masters of Tuscany they would become powerful enough to lay hands on the Lombard provinces. There were still other motives for Andrea’s jealousy of the power of the Farnese family. A member of the Doria house named Imperiale being reduced to extreme poverty had obtained an appointment in the army of Andrea. He distinguished himself in many actions and rose to the highest honours and wealth. But having satisfied his military ambition he became a priest, in which character he was first abbott of San Fruttuoso and afterwards, through the influence of Andrea, bishop of Sagona in Corsica. Wishing, however, to advance his worldly interests he retired into Apulia where he acquired many estates, and was elevated by Andrea to the government of Melfi, in which he largely increased his wealth.