The President of the United States, in view of the limited appropriation by Congress, and the economy of short voyages, has recommended one of the great interoceanic routes through the American isthmus for a new negro colony. It is a great object to secure the control of this isthmus by a friendly race, born on our soil, and the selection corresponds with the views expressed in my Texas letter of 1844. As, however, the negroes can only be colonized by their own consent, we should therefore, and as an act of humanity and justice, open all suitable homes abroad for their free choice. After much reflection, I think it is their interest and ours (when the nation shall make large and adequate appropriations), mainly to seek Liberia as a permanent home, establishing there, among their own race, and in the land of their ancestors, a great republic. Liberia has already largely contributed to the decline of the African slave trade. She has reclaimed from barbarism, for civilization, Christianity, liberty, and the English language, 700 miles of the coast, running far into the interior, reaching a high, healthy, well watered, rich, and beautiful country. She has already civilized and Christianized 300,000 native Africans, and brought them into willing obedience to her government. As her power extends along the coast and into the interior, she may soon extinguish the slave trade. This would relieve our squadron, stationed by treaty on the African coast to suppress that traffic, and leave the large sums, annually expended by Congress for that purpose, to be applied in further aid of the cause of colonization. Providence, for several centuries, has mysteriously connected our destiny with that of the African race. This rebellion developes that purpose; the civilization of that race here, and their transfer to the land of their fathers, carrying with them our language, laws, religion, and free institutions, redeemed from the curse of slavery. Now, indeed, we see the approaching fulfilment of prophecy, when 'Ethiopia shall stretch forth her hands unto God.' We have just established commercial and diplomatic relations with Liberia, and, in separating from the race here, let us do them ample justice. Let us purchase for Liberia (which can be done for a small sum), the great adjacent coast and interior of Africa, and thus eventually evangelize and civilize that whole region. Liberia would thus expand and become the great Afric-American republic, and the dominant nation of that immense continent. Commerce, the first great missionary--like St. John in the wilderness, preceding the advent of the Redeemer--would penetrate that dark region, and the execrable trade in human beings, give way to the interchange of products and manufactures.