The patient now falls into a listless, motionless state in which, however, the apathy is more apparent than real. The algidity may deepen and death ensue or the stage of reaction may set in. The algid stage may last from a few hours to two or three days. Collapse and uraemia are the two most frequent causes of death. _Stage of Reaction._—The pulse returns, urine is again secreted and the duskiness and coldness of the skin give way to normal conditions and a favorable convalescence sets in. At other times, however, the rise of surface temperature and restoration of the circulation are not attended by urinary secretion. In such cases a typhoid state ensues with accelerated respiration, dry, brown tongue and muttering delirium. It is customary to divide the types of cholera cases into: 1. _Cholera gravis._ The type above described. 2. _Cholerine._ In this there is a more or less marked stage of evacuation with possibly the appearance of rice-water stools. The urine, however, does not become suppressed and the algid stage is not entered upon. 3. _Cholera sicca._ This type of the disease is more apt to be seen in old or debilitated people. The patient dies of collapse without showing symptoms of vomiting or diarrhoea. At the autopsy one may find the bowels distended with rice-water contents. The so-called _cholera ambulans_ is simply another designation for the more or less ill cholera carrier. =Sequelae.=—Following an attack of cholera we may have abscess of the parotid gland or gangrene of various parts of the body. There may be ulceration of the cornea. In pregnant women the disease almost invariably causes abortion. Post-choleraic pneumonias and renal inflammations are to be considered. Symptoms in Detail _General Appearance._—A typical case of cholera, with its cyanosed, drawn, pinched face, cold, clammy skin and the eyes deeply sunken in the orbits, makes a picture rarely seen in other conditions. The washerwoman’s hands appearance should always be looked for. _Temperature Record._—The temperature of the skin surface is lowered from the normal while that of the rectum may be normal or even elevated. There may be a difference of 10° or more between rectal and surface temperature. In the stage of reaction the temperature may continue to rise to high fever points and this so-called hyperthermic type is very fatal.