_The Eye._—In nodular leprosy eye lesions, chiefly leprotic nodules in conjunctivae or iris, with subsequent ulceration, are met with at some time in the course of the disease in almost 90% of cases. In nerve leprosy, corneal ulcerations, chiefly resulting from paralyses of the facial muscles, with ectropion, give eye symptoms in about 45% of cases. _Genito-urinary Symptoms._—Atrophy of the testicles with increase of connective tissue often result in males but data would indicate that the procreative power of the female is but little diminished. Lepers often die of renal complications, the kidney lesions being rather those of amyloid change. Bacilli may be eliminated in the urine during accessions of fever. _The Lymphatic Glands._—These tend to enlarge and show bacilli, but rarely suppurate. The inguinal and cervical glands are most often enlarged. _The Blood._—The changes, other than those of a secondary anaemia as the disease progresses, are not characteristic. Bacilli are present in the blood of cases of nodular leprosy quite constantly but less so in that of cases of nerve leprosy. The bacilli are more apt to be found in the blood at the time of febrile accessions. DIAGNOSIS =Clinical Diagnosis.=—It must be remembered that leprosy is very slow in development, so that for months or even years there may be but slight indications of the disease, as an anaesthetic spot or the palsy of an orbicularis palpebrarum. One should always run over the lobes of the ears or region of the eyebrows to feel for shot-like nodules. In the making of a diagnosis the information as to possible exposure to the disease is of first importance. The leprous spots are at first rather oily from increased action of the sebaceous glands but subsequently become dry. In ancient times the hypersecretion of sebaceous material about the facial spots of nodular leprosy served as the basis of a test for leprosy, the suspected eruption being dashed with water. If the surface was not wetted it was a point in favor of leprosy. Of prime importance however is the pin prick for anaesthesia, which is the most important distinguishing characteristic, next to the finding of the bacilli, for a leprous spot. The anaesthesia is more marked in the center of the spot and may show dissociation of sensation. It is very important to examine for enlargement of the ulnar or great auricular and the earliest signs of a nerve leprosy may be anaesthesia and a slight contraction of the ring and little finger.