When, at the present day, we hear of an epidemic of small-pox in some town where the practice of vaccine inoculation has been neglected, it is both instructive and consolatory to turn our thoughts back to the time, before the introduction of that practice, when that horrible disease caused ten per cent, of all the deaths in excess of those occurring in the ordinary course of nature. This statement, startling as it may seem to the present generation, may be verified by reference to the annual bills of mortality of the city of London. This fearful state of things had prevailed in England from the time of the Plantagenets, when, in the first quarter of the eighteenth century, a gleam of light was flashed upon the medical darkness of western Europe from the east. Lady Mary Wortley Montagu, writing from Adrianople to a lady friend in the spring of 1717, flashed that light in the concluding portion of her letter, as follows:-- "Apropos of distempers, I am going to tell you a thing that will make you wish yourself here. The small-pox, so fatal and so general amongst us, is here entirely harmless, by the invention of _ingrafting_, which is the term they give it. There is a set of old women who make it their business to perform the operation every autumn, in the month of September, when the great heat is abated. People send to one another to know if any of their family has a mind to have the small-pox; they make parties for this purpose, and when they are met (commonly fifteen or sixteen together), the old woman comes with a nut-shell full of the matter of the best sort of small-pox, and asks what vein you please to have opened. She immediately rips open that you offer to her with a large needle (which gives you no more pain than a common scratch), and puts into the vein as much matter as can lie upon the head of her needle, and after that binds up the little wound with a hollow bit of shell, and in this manner opens four or five veins. ... Every year thousands undergo this operation; and the French ambassador says pleasantly, that they take the small-pox here by way of diversion, as they take the waters in other countries. There is no example of any one that has died in it; and you may believe I am well satisfied of the safety of this experiment, since I intend to try it on my own little son." This intention she carried into practice, and on her return to England made great exertions to introduce inoculation into general use. The medical profession opposed it so strongly, however, that for many years the horrible distemper continued to rage unchecked. Such announcements as the following were, in consequence, not unfrequent in the newspapers:--