The condition and strength of the dog, and the season of the year, will be our best guides. If the patient has not lost much flesh, and is not losing it at the time that we have to do with him, and has few symptoms of general debility, and spring or summer are approaching we may with tolerable confidence predict a cure; but, if he has been rapidly losing ground, and is doing so still, and staggers about and falls, there is no medicine that will restore him. 5th October, 1840.--A pointer, eighteen months old, had had the distemper, but not severely, and was apparently recovering when he suddenly lost all voluntary power over his limbs. He was unable to get up, and his legs were in constant, rapid, and violent motion. This continued three days, during which he had refused all food, when, the dog being in the country, my advice was asked. I ordered a strong emetic to be given to him, and after that a dose of Epsom salts, the insertion of a seton, and, in addition to this, our usual tonic was to be given twice every day. His food to consist chiefly of good strong soup, which was to be forced upon him in a sufficient quantity. In two days he was able to get up and stagger about, although frequently falling. His appetite returned. He continued to improve, and most rapidly gained strength and especially flesh. A very peculiar, high-lifting, clambering, and uncertain motion of the legs remained, with an apparent defect of sight, for he ran against almost everything. In six weeks the seton was removed, and the dog remained in the same state until the 7th of December. The uncertain clambering motion was now increasing, and likewise the defect of sight. He ran against almost every person and every thing. The cornea was transparent, the iris contracted, there was no opacity of the lens, or pink tint of the retina, but a peculiar glassy appearance, as unconscious of everything around it. An emetic was given, and, after that, an ounce of sulphate of magnesia. 8th. He was dreadfully ill after taking the salts; perhaps they were not genuine. For two days he panted sadly, refused his food, and vomited that which was forced upon him. His muzzle was hot; he could scarcely stand; he lost flesh very rapidly. An emetic was given immediately, and a distemper-ball daily. 16th. He soon began rapidly to recover, until he was in nearly the same state as before, except that the sight was apparently more deficient. The sulphate of magnesia was given every fourth day, and another seton inserted. 21st. He continued the medicine, and evidently improved, the sight returning, and the spasms being considerably less. The distemper-ball was continued. 4th January, 1841.--The spasms were better; but the vision did not improve. In the afternoon he fell into a momentary fit. He almost immediately rose again, and proceeded as if nothing had happened. An ounce of Epson salts was given, and then the tonic balls as before.