22d. The dog, probably neglected at home, was sent to me. Both ears were as bad as ever. 25th. The dog is perfectly unmanageable when the lotion is poured into the ear, but submits when an ointment is applied. Use ung. sambuci, [Symbol: ounce] j. cerus, acet. [Symbol: ounce] j., mix well together. Continue the alteratives. 30th. Slowly amending; the whining has ceased, and the animal seldom scratches. Continue the lotion, alteratives, and purgatives. 10th Oct.--Slowly improving. Continue the treatment. 17th. One ear well, the other nearly so. 24th. Both ears were apparently well. Omit the lotion. 28th. One ear was again ulcerated. Applied the aerugo aeris. 31st. This has been too stimulating, and the ulceration is almost as great as at first. Return to the ung. sambuci and cerusa acetata. From this time to the 24th February, 1833, we continued occasionally taking out the seton, but returning to it every two or three days; applying the canker lotion until we were driven from it, mixing with it variable quantities of tinctura opii, having recourse to mercurial ointment, and trying a solution of the sulphate of copper. With two or three applications we could keep the disease at bay; but with none could we fairly remove the evil. The sulphate of zinc, the acetate of lead, decoctions of oak bark, a very mild injection of the nitrate of silver,--all would do good at times; but at other times we were set at complete defiance. Another gentleman brought his dog about the same time. This was also a Newfoundland dog. He had always been subject to mangy eruptions, and had now mange in the feet, the inside of the ear covered with scaly eruptions, the skin red underneath, considerable thickening of the ear, and a slight discharge from its base. A seton was inserted and a physic-ball given every second day. The canker lotion had little good effect. Some calamine ointment, with a small portion of calomel, was then had recourse to. In ten days the dog had ceased to scratch himself or shake his head, and the ear was clean and cool. The seton was removed; but the animal being confined, a little redness again appeared in the ear, which the lotion soon removed. At the expiration of a month he was dismissed apparently cured; but he afterwards had a return of his old mangy complaints, which bade defiance to every mode of treatment. Herr Maassen, V. S., Wümemburg, has lately introduced, and with much success, the use of creosote for the cure of canker in the ear.