A harsh hollow cough is attended by more inflammatory action. The depletive system must be adopted here. A loud and harsh cough will yield only to the lancet and to purgatives, assisted by sedative medicines composed of nitre, antimonial powder, and digitalis, or small doses of syrup of poppies, or more minute doses of the hydrocyanic acid; this last medicine, however, should be carefully watched, and only given under surgical advice. 28th October, 1842. A spaniel was apparently well yesterday, but towards evening a violent cough suddenly came on. It was harsh and hollow, and terminated in retching. There was a discharge of water from the eyes; but the nose was cool and moist. Give an emetic, and then two grains of the James's powder. 29th The animal coughed almost the whole of the night. There was more watery discharge from the eyes, which appeared to be red and impatient of light; the nose continued cool, and the dog did not refuse his food. An aperient ball was given; and twice afterwards in the day, the nitre, antimonial powder, and digitalis. 30th. The cough is as frequent, but not very loud. Give a mixture of syrup of poppies and prussic acid morning and night, and the ball as yesterday. 31st. Nearly in the same state as yesterday, except that he is not so thirsty, and does not eat so well. Give the mixture three times daily. Nov. 1st. He had an emetic in the morning, which produced a large quantity of phlegm, but the cough is no better. No evacuation during the two last days. Give an aperient ball, and the mixture as before in the evening. The prussic acid has been fairly tried; it has not in the least mitigated the cough, but begins to make the dog sick, and altogether to destroy his appetite. Give three times in the day a mixture consisting of two-thirds of a drachm of syrup of poppies, and one-third of syrup of buckthorn. The sickness ceased, and the cough remained as before, I then gave twice in the day half a grain of calomel, the same of opium, two each of pulvis antimonialis and digitalis, and four grains of nitre, morning and noon, with six grains of the Dover's powder at night. This was continued on the 3d, 4th and 5th of November, when there were longer intervals of rest, and the dog did not cough so harshly when the fit was on him. On the 6th, however, no medicine was given; but towards evening the dog coughed as much as ever, and a decided mucous discharge commenced from the nose and the eyes, with considerable snorting. An emetic was given, and the balls resorted to as before. '7th.' He appeared to be much relieved by the emetic. The cough was better, the dog ate well, and had regained his usual spirits. The ball as before.