4 P.M.--No better: gave him pulv. aloes [Symbol: ounce] j.; calomel, gr. vj. et pulv. opii gr. viij. The fomentations to be continued, and the abdomen rubbed with a lin. terebinthinæ. 5 P.M.--A great change has taken place within the last hour; the hind extremities are paralysed; the mouth and ears are cold; the pulse is more hurried and irregular, and almost imperceptible; the respiration is laborious and irregular, as is the pulse; and the dog is frequently sick. To be kept quiet. 6 P.M.--Another change: he lies panting and groaning piteously; his limbs are bathed in sweat, with convulsive struggles. At twenty minutes past six he died. A post-mortem examination presented general marks of inflammation; the small intestines were extremely red, while the large ones were in a gangrenous state and most offensive, with a rupture of the colon. I did not expect to meet with the rupture, and am at a loss to account for it. The liver was of a pale ashen colour, and very light. I put a piece of it into some water, and it floated on the surface. The other contents of the abdomen did not show the slightest appearance of disease. September 2d, 1843.--A black pug-bitch, 18 months old, was yesterday taken violently sick; the vomiting continued at intervals the greater part of the day, and she had not eaten during the last 24 hours. I could not possibly get at her, on account of her ferocity: as she had not had the distemper, and as I was misled by her age and the watery discharge from her eyes, and as she had had several motions yesterday, I imagined that the attack might be the beginning of that disease. Learning that she was fond of sweet things, I prepared an emetic containing a grain of calomel and a grain of tartar emetic: she took it readily, and I promised to call on the following day. Sept. 3.--The weakness at the eyes had disappeared, but there had been no motion. On getting at her by main force I found her belly very tense and rather hot: she had again been sick, was very eager for water, and still refused to eat. The disease was now evident. As she appeared too unmanageable for anything else, I produced a physic-ball, in giving which I was bitten. Six hours afterwards I again went: no fæces had passed: I administered two enemas, the second of which was returned with a small quantity of hardened fæces and an intolerable smell. I ordered the water to be removed, and broth to be substituted. Sept. 4.--The dog is in good spirits, has eaten heartily, and had no motion, probably because it was habitually cleanly, and had not been taken out of doors. Her owner considered her as quite well, and dismissed me. Three days afterwards a servant came to say that all was going on very well. PERITONITIS.