The vaccine inoculation was effected with great difficulty in India; an immense number of experiments failed, chiefly owing to the _virus_ having been destroyed on the way from Constantinople, whence matter was repeatedly forwarded by Lord Elgin to Dr. Short, at Bagdad. A whole year was passed under the most mortifying disappointments; but in June, 1802, a successful inoculation was made at Bombay, on a healthy child, about three years of age; which furnished a supply for every port of India. By shipping several children, who had never experienced the variolous inoculation, a succession of subjects was happily secured, which enabled Dr. Anderson to transmit the blessings afforded by this mitigated disease, even to Port Jackson. The greatest apprehensions entertained, arose from the danger of not being always provided with a succession of infective matter; for it was soon discovered, that the _virus_ was highly volatile, and often made its escape in conveying the _pus_ from one house to another. This, added to the necessity, which soon became apparent, for the formation of some depôt, and for the establishment of certain principles necessary towards the desired success, caused the Governor-General to nominate Mr. William Russell, of the Bengal Medical List, whose abilities and zeal peculiarly qualified him, to the important situation of Superintendant of the Vaccine Institution. A series of ill health, which ultimately compelled that gentleman to return to Europe, caused the records of the first months to be somewhat inaccurate, notwithstanding every exertion on his part. His assiduity, however, enabled him to register almost every child, born of European parents, at that time in the settlement, among those who received this benign and inoffensive substitute for the most malignant, loathsome, and fatal disease that ever afflicted the human race.