+---------+ | | ISAAC I., John. 1057–1059. | | ALEXIUS I., 1081–1118, _m._ Irene. | +-------------------------+-----+------------------+------------+ | | | | Anna, JOHN II., Isaac. Theodora. _m._ Nicephorus Bryennius. 1118–1143, | | _m._ Irene of | | Hungary. | | | | | +---------------+------------+ | | | | | | Isaac, MANUEL I., | | grandfather of 1143–1180, | | Isaac, _m._ 1. Bertha of | | Emperor of Sulzbach, Louis VII. | | Cyprus. 2. Mary of of France. | | Antioch. | | | | | | | ALEXIUS II., _m._ 1. Agnes _m._ 2. ANDRONICUS I., | 1180–1183. of France. 1183–1185. | | | Manuel. | | | Alexius, | founder of line | of Emperors of | Trebizond. | | +------------+-----------------+---------------------+ | | | Andronicus. John. Michael, | | Despot of Epirus, | Theodore, founder of line | Emperor of of Despots of | Thessalonica, Epirus. | 1214–1230. +---------------+---+ | | ALEXIUS III., ISAAC II., _m._ 1. Margaret _m._ 2. Boniface of Montferrat, 1195–1203. 1185–1195, of | King of Thessalonica,