The treatment is technical, and is given in detail in books like De Lee's _Principles and Practice of Obstetrics_.[136] Suggestion and the environment are important elements in the treatment. Local anesthetics, mechanical drugs like cerium oxalate and bismuth, depressomotors, external applications, and gastric lavage are indicated in the early stages of the disease, but are rather harmful than useful in later stages. Adrenalin, ten drops of a 1:1000 solution by mouth, or three drops hypodermically as doses, often cures. Sergent and Lian reported six such cases in one paper in 1913. Hypodermic injection of the extract of corpus luteum in 1 c.c. doses has been effective in some cases. So has the injection of defibrinated serum from a healthy pregnant woman. Curtis describes the technic in the _Journal of the American Medical Association_, February 28, 1914. The gynecologist must adjust uterine displacements and heal cervical erosions. The oculist, laryngologist, and otologist are to remedy refractive errors and remove irritants in the air passages and the ear. [136] Philadelphia, 1913. The treatment of last resort is to empty the uterus. This will cure all cases of neurotic and reflex origin if done early enough. In these cases, if the therapeutic abortion is deferred until very late, the patient will die of exhaustion. Toxemic cases do not react well after therapeutic abortion because of the damage previously done by the circulating poison, especially in the liver. A positive diagnosis of toxemia cannot always be made, and many patients in whom the diagnosis has been made correctly recover without abortion. Apart from moral considerations, it is very difficult to determine the proper time to empty the uterus. A test is made of the glycolytic power of the liver by giving two ounces of levulose internally; and if sugar shows in the urine, this means that the liver is unable to act normally, that it has been attacked and disabled by the toxin, and therefore the therapeutic abortion should be done. Again, a marked concentration of the blood, shown by erythrocytosis and leucocytosis, indicates starvation. Some obstetricians perform abortion when the pulse remains above 100, at the appearance of fever, blood from the stomach, jaundice, albuminuria, mellituria, acetonuria, indicanuria, or marked loss of weight. Polyneuritis, with icterus and bile in the urine, is another indication for abortion; a patient may die from polyneuritis alone after the hyperemesis has ceased. Not one but all these facts must be considered, together with one's own clinical experience.