The older theories of impregnation generally went astray in regarding the large ovum as the sole base of the new organism, and only ascribed to the spermatozoon the work of stimulating and originating its development. The stimulus which it gave to the ovum was sometimes thought to be purely chemical, at other times rather physical (on the principle of transferred movement), or again a mystic and transcendental process. This error was partly due to the imperfect knowledge at that time of the facts of impregnation, and partly to the striking difference in the sizes of the two sexual cells. Most of the earlier observers thought that the spermatozoon did not penetrate into the ovum. And even when this had been demonstrated, the spermatozoon was believed to disappear in the ovum without leaving a trace. However, the splendid research made in the last three decades with the finer technical methods of our time has completely exposed the error of this. It has been shown that the tiny sperm-cell is NOT SUBORDINATED TO, BUT COORDINATED WITH, the large ovum. The nuclei of the two cells, as the vehicles of the hereditary features of the parents, are of equal physiological importance. In some cases we have succeeded in proving that the mass of the active nuclear substance which combines in the copulation of the two sexual nuclei is originally the same for both. These morphological facts are in perfect harmony with the familiar physiological truth that the child inherits from both parents, and that on the average they are equally distributed. I say "on the average," because it is well known that a child may have a greater likeness to the father or to the mother; that goes without saying, as far as the primary sexual characters (the sexual glands) are concerned. But it is also possible that the determination of the latter--the weighty determination whether the child is to be a boy or a girl--depends on a slight qualitative or quantitative difference in the nuclein or the coloured nuclear matter which comes from both parents in the act of conception.