The same kind of coelom-formation as in sagitta was afterwards found by Kowalevsky in brachiopods and other invertebrates, and in the lowest vertebrate--the amphioxus. Further instances were discovered by two English embryologists, to whom we owe very considerable advance in ontogeny--E. Ray-Lankester and F. Balfour. On the strength of these and other studies, as well as most extensive research of their own, the brothers Oscar and Richard Hertwig constructed in 1881 the Coelom Theory. In order to appreciate fully the great merit of this illuminating and helpful theory, one must remember what a chaos of contradictory views was then represented by the "problem of the mesoderm," or the much-disputed "question of the origin of the middle germinal layer." The coelom theory brought some light and order into this infinite confusion by establishing the following points: 1. The body-cavity originates in the great majority of animals (especially in all the vertebrates) in the same way as in sagitta: a couple of pouches or sacs are formed by folding inwards at the primitive mouth, between the two primary germinal layers; as these pouches detach from the primitive gut, a pair of coelom-sacs (right and left) are formed; the coalescence of these produces a simple body-cavity. 2. When these coelom-embryos develop, not as a pair of hollow pouches, but as solid layers of cells (in the shape of a pair of mesodermal streaks)--as happens in the higher vertebrates--we have a secondary (cenogenetic) modification of the primary (palingenetic) structure; the two walls of the pouches, inner and outer, have been pressed together by the expansion of the large food-yelk. 3. Hence the mesoderm consists from the first of TWO genetically distinct layers, which do not originate by the cleavage of a primary simple middle layer (as Remak supposed). 4. These two middle layers have, in all vertebrates, and the great majority of the invertebrates, the same radical significance for the construction of the animal body; the inner middle layer, or the visceral mesoderm, (gut-fibre layer), attaches itself to the original entoderm, and forms the fibrous, muscular, and connective part of the visceral wall; the outer middle layer, or the parietal mesoderm (skin-fibre-layer), attaches itself to the original ectoderm and forms the fibrous, muscular, and connective part of the body-wall. 5. It is only at the point of origination, the primitive mouth and its vicinity, that the four secondary germinal layers are directly connected; from this point the two middle layers advance forward separately between the two primary germinal layers, to which they severally attach themselves. 6. The further separation or differentiation of the four secondary germinal layers and their division into the various tissues and organs take place especially in the later fore-part or head of the embryo, and extend backwards from there towards the primitive mouth.