(FIGURE 2.353. Gut of a dog-embryo (shown in Figure 1.202, from Bischoff), seen from the ventral side, a gill-arches (four pairs), b rudiments of pharynx and larynx, c lungs, d stomach, f liver, g walls of the open yelk-sac (into which the middle gut opens with a wide aperture), h rectum. FIGURE 2.354. The same gut seen from the right. a lungs, b stomach, c liver, d yelk-sac, e rectum.) There is at first only one pair of gill-clefts in the Amphioxus, as in the Ascidia and Enteropneusts; and the Copelata (Figure 2.225) have only one pair throughout life. But the number presently increases in the former. In the Craniotes, however, it decreases still further. The Cyclostomes have six to eight pairs (Figure 2.247); some of the Selachii six or seven pairs, most of the fishes only four or five pairs. In the embryo of man, and the higher Vertebrates generally, where they make an appearance at an early stage, only three or four pairs are developed. In the fishes they remain throughout life, and form an exit for the water taken in at the mouth (Figures 2.249 to 2.251). But they are partly lost in the amphibia, and entirely in the higher Vertebrates. In these nothing is left but a relic of the first gill-cleft. This is formed into a part of the organ of hearing; from it are developed the external meatus, the tympanic cavity, and the Eustachian tube. We have already considered these remarkable structures, and need only point here to the interesting fact that our middle and external ear is a modified inheritance from the fishes. The branchial arches also, which separate the clefts, develop into very different parts. In the fishes they remain gill-arches, supporting the respiratory gill-leaves. It is the same with the lowest amphibia, but in the higher amphibia they undergo various modifications; and in the three higher classes of Vertebrates (including man) the hyoid bone and the ossicles of the ear develop from them. (Cf. Chapter 2.25.) (FIGURE 2.355. Median section of the head of a Petromyzon-larva. (From Gegenbaur,) h hypobranchial groove (above it in the gullet we see the internal openings of the seven gill-clefts), v velum, o mouth, c heart, a auditory vesicle, n neural tube, ch chorda.)