In all the Anamnia (the lower amnionless Craniotes, Cyclostomes, Fishes, Dipneusts, and Amphibia) the urinary organs remain at a lower stage of development to this extent, that the primitive kidneys (protonephri) act permanently as urinary glands. This is only so as a passing phase of the early embryonic life in the three higher classes of Vertebrates, the Amniotes. In these the permanent or after or secondary (really tertiary) kidneys (renes or metanephri) that are distinctive of these three classes soon make their appearance. They represent the third and last generation of the vertebrate kidneys. The permanent kidneys do not arise (as was long supposed) as independent glands from the alimentary tube, but from the last section of the primitive kidneys and the nephroduct. Here a simple tube, the secondary renal duct, develops, near the point of its entry into the cloaca; and this tube grows considerably forward. With its blind upper or anterior end is connected a glandular renal growth, that owes its origin to a differentiation of the last part of the primitive kidneys. This rudiment of the permanent kidneys consists of coiled urinary canals with Malpighian capsules and vascular coils (without ciliated funnels), of the same structure as the segmental mesonephridia of the primitive kidneys. The further growth of these metanephridia gives rise to the compact permanent kidneys, which have the familiar bean-shape in man and most of the higher mammals, but consist of a number of separate folds in the lower mammals, birds, and reptiles. As the permanent kidneys grow rapidly and advance forward, their passage, the ureter, detaches altogether from its birth-place, the posterior end of the nephroduct; it passes to the posterior surface of the allantois. At first in the oldest Amniotes this ureter opens into the cloaca together with the last section of the nephroduct, but afterwards separately from this, and finally into the permanent bladder apart from the rectum altogether. The bladder originates from the hindmost and lowest part of the allantoic pedicle (urachus), which enlarges in spindle shape before the entry into the cloaca. The anterior or upper part of the pedicle, which runs to the navel in the ventral wall of the embryo, atrophies subsequently, and only a useless string-like relic of it is left as a rudimentary organ; that is the single vesico-umbilical ligament. To the right and left of it in the adult male are a couple of other rudimentary organs, the lateral vesico-umbilical ligaments. These are the degenerate string-like relics of the earlier umbilical arteries.