But neither Sanctorius nor Harvey had the immediate influence upon their contemporaries which the novel and stimulating character of their work justified. Harvey's great contemporary, Bacon, although he lost his life in making a cold storage experiment, did not really appreciate the enormous importance of experimental science. He looked very coldly upon Harvey's work. It was a philosopher of another kidney, Rene Descartes, who did more than anyone else to help men to realize the value of the better way which Harvey had pointed out. That the beginning of wisdom was in doubt, not in authority, was a novel doctrine in the world, but Descartes was no armchair philosopher, and his strong advocacy and practice of experimentation had a profound influence in directing men to "la nouvelle methode." He brought the human body, the earthly machine, as he calls it, into the sphere of mechanics and physics, and he wrote the first text-book of physiology, "De l'Homme." Locke, too, became the spokesman of the new questioning spirit, and before the close of the seventeenth century, experimental research became all the mode. Richard Lower, Hooke and Hales were probably more influenced by Descartes than by Harvey, and they made notable contributions to experimental physiology in England. Borelli, author of the famous work on "The Motion of Animals" (Rome, 1680-1681), brought to the study of the action of muscles a profound knowledge of physics and mathematics and really founded the mechanical, or iatromechanical school. The literature and the language of medicine became that of physics and mechanics: wheels and pulleys, wedges, levers, screws, cords, canals, cisterns, sieves and strainers, with angles, cylinders, celerity, percussion and resistance, were among the words that now came into use in medical literature. Withington quotes a good example in a description by Pitcairne, the Scot who was professor of medicine at Leyden at the end of the seventeenth century. "Life is the circulation of the blood. Health is its free and painless circulation. Disease is an abnormal motion of the blood, either general or local. Like the English school generally, he is far more exclusively mechanical than are the Italians, and will hear nothing of ferments or acids, even in digestion. This, he declares, is a purely mechanical process due to heat and pressure, the wonderful effects of which may be seen in Papin's recently invented 'digester.' That the stomach is fully able to comminute the food may be proved by the following calculation. Borelli estimates the power of the flexors of the thumb at 3720 pounds, their average weight being 122 grains. Now, the average weight of the stomach is eight ounces, therefore it can develop a force of 117,088 pounds, and this may be further assisted by the diaphragm and abdominal muscles the power of which, estimated in the same way, equals 461,219 pounds! Well may Pitcairne add that this