All these things were torture to the heart of Isabella and to her parents, who saw their new-found happiness so soon disturbed. The lady keeper advised the queen that to prevent the mischief which might break out between her own family and Richard's, the possible cause of it should be withdrawn, by sending Isabella to Spain. In support of this suggestion she added that Isabella was a Catholic, and so rooted in that faith, that all the arguments and persuasions she had used to withdraw her from it, and they were many, were of no avail. The queen replied that she esteemed her the more, since she was steadfast to the law taught her by her parents; and that as for sending her to Spain, it was not to be thought of, for she was charmed with her lovely presence and her many graces and virtues. In fine, the queen was resolved that Isabella should become Richard's wife, if not that day, on another, without fail. The lady keeper was so mortified by this reply that she withdrew without saying a word; and having already made up her mind that unless Isabella was removed there could be no hope of relief for her son or of peace between him and Richard, she determined to commit one of the most atrocious acts that could enter the mind of a lady of her exalted station. Women being, for the most part, rash and sudden in the execution of their resolves, the lady keeper that evening gave Isabella poison in a conserve which she pressed her to take, under the pretence that it was good for the sinking and oppression of the heart which she complained of. A short while after Isabella had swallowed it her throat and tongue began to swell, her lips turned black, her voice became hoarse, her eyes fixed and glassy, and her breathing laboured and stertorous: in short, she exhibited all the symptoms of having been poisoned. The queen's ladies hastened to inform her majesty, assuring her that the lady keeper had been the author of the nefarious deed. The queen had no great difficulty in coming to the same conclusion, and went at once to see Isabella, who seemed to be almost at the last gasp. Sending with all speed for her physicians, she, meanwhile, ordered that the sufferer should be given a quantity of powdered unicorn's horn and several other antidotes, with which great princes are usually provided against such casualties. The physicians arrived and begged the queen to make the lady keeper declare what kind of poison she had used (for no one doubted that she was the poisoner). This information having been obtained from the criminal, the physician applied the proper remedies with such good effect that, with God's help, Isabella's life was saved, or at least there was a hope that it would be so.