The distemper, when existing in its worst form, is very often mistaken for canine madness; but a close attention to the following points will with certainty show the difference. Puppies are not so liable to madness as full-grown dogs; it is but seldom the animal will drink freely in the distemper, never in madness—yet they will now and then try to drink; the hydrophobia arrives likewise at its height, in general, sooner than the distemper, although the latter is sometimes equally sudden in its attack, and rapid in its progress. In madness, all recollection of places or persons is lost by the affected animal; his home will be left, and he will bite the hand that feeds him, indiscriminately with any other. In the distemper, there is no loss of reason but in the attack and actual continuance of the convulsion fits; the animal does not attempt to bite or rove abroad, and, on recovery from the fit, resumes his faculties. If, therefore, a young dog will drink when the immediate effect of the spasmodic restriction is removed, or, without evident fear, will bear the sight of water, but more particularly when his weakness is excessive, and strongly apparent between the intervals of the fits, it may be safely concluded that it is the distemper, and not madness. These circumstances, continues Mr. Blaine, should be carefully remarked, as they are unerring, and may save many a valuable animal from destruction, and many a timid mind from the most dreadful apprehension. * * * * * For the distemper, so soon as the symptoms appear, give an ounce of castor oil, and after its operation has ceased, give the following powder, mixed up with butter, into a bolus, every two hours, keeping the dog warm, and supplying him frequently with warm milk or water-gruel. Should the medicine occasion sickness or purging, the quantity and frequency of the doses are to be abated. Crocus metallorum finely levigated, and white antimonial powder, each six grains, and diaphoretic calx of antimony, ten grains for one dose. It is necessary to remark, that the above dose is sufficient for a pointer or fox-hound, of six or eight months old, and that the quantity is to be varied according to the size and age of the dog. Rhubarb and jalap mixed, as much as will lie on a shilling, is an excellent common physic. For dogs, foul within, five grains of tartar emetic, given in a piece of hog’s lard. For a surfeit, one ounce of sulphur, half an ounce of antimony, mixed together; a small ball in butter, to be given to the dog, and the sore place well rubbed with a mixture of white hellebore-root powdered, and hog’s lard; the dog to be kept from water if he licks the ointment. * * * * * Doctor Darwin has given the following opinion upon the disorder, and how to counteract its malignity.