Between these old cities, for whose sites European nations contended, stand the cities whose growth preeminently represents the Ohio valley; Cincinnati, the historic queen of the river; Louisville, the warder of the falls; the cities of the "Old National Road," Columbus, Indianapolis; the cities of the Blue Grass lands, which made Kentucky the goal of the pioneers; and the cities of that young commonwealth, whom the Ohio river by force of its attraction tore away from an uncongenial control by the Old Dominion, and joined to the social section where it belonged. The Ohio Valley is, therefore, not only a commercial highway, it is a middle kingdom between the East and the West, between the northern area, which was occupied by a greater New England and emigrants from northern Europe, and the southern area of the "Cotton Kingdom." As Pennsylvania and New York constituted the Middle Region in our earlier history, between New England and the seaboard South, so the Ohio Valley became the Middle Region of a later time. In its position as a highway and a Middle Region are found the keys to its place in American history. From the beginning the Ohio Valley seems to have been a highway for migration, and the home of a culture of its own. The sciences of American archeology and ethnology are too new to enable us to speak with confidence upon the origins and earlier distribution of the aborigines, but it is at least clear that the Ohio river played an important part in the movements of the earlier men in America, and that the mounds of the valley indicate a special type of development intermediate between that of the northern hunter folk, and the pueblo building races of the south. This dim and yet fascinating introduction to the history of the Ohio will afford ample opportunity for later students of the relations between geography and population to make contributions to our history.