It appears that he had taken holy orders during his abode at Rome, for before his departure Sixtus IV. bestowed on him a reversionary grant of the first benefice which should fall vacant. This proved to be Uceda; and he immediately produced his letters and took possession. The Archbishop of Toledo, who had already promised the living, was highly offended at this exercise of what in truth was a most objectionable prerogative of the Holy See. He not only dispossessed, but imprisoned for six years, Ximenes, who remained firm in the assertion of his rights. At the end of that time the prelate yielded. Ximenes soon exchanged Uceda for a chaplaincy in the cathedral of Siguenza. Here he applied himself to the pursuit of theology, and laid the foundation of that Hebrew and Chaldaic learning which bore such noble fruit in after-life. He gained the warm friendship of his bishop, the Cardinal Mendoza, who, in 1483, appointed him grand vicar of the diocese. In that office he distinguished himself by integrity and talents for business, as he had before by piety and learning. And the fairest prospect of advancement was open to him, when all at once he resolved to quit the world, and to devote himself wholly to religious meditation. He embraced the strictest rule of the Franciscan order, with a zeal to which the general example of his brethren gave no countenance. He retired to the secluded monasteries of Castagnar and Salceda, and in the forests which surrounded them, devoted himself wholly to prayer, the study of the Scriptures, and the mortification of the flesh. He thus gained the reputation of uncommon sanctity, and there seems to be no reason to think that his asceticism was defiled by any trace of hypocrisy. But his friend the Cardinal saw that he was fitted for still better things, and regretting his departure from active life, expressed a belief that he would ultimately be raised to much higher dignity, to the great advantage of the Church. And, in truth, the Cardinal, who had been raised from the see of Siguenza to the primacy of Spain, the Archbishopric of Toledo, did much to fulfil his own prediction. He introduced Ximenes to the Queen Isabella, who was then in want of a confessor, and she readily listened to his recommendation, and appointed Ximenes to the vacant office. He would fain have declined it, urging that he had been called to the cloister from active life to attend to his own salvation; that what was demanded would withdraw him from his proper vocation; and that a sovereign above all persons needed a religious guide, not only of good intentions, but of experience and wisdom. The Queen smiled as she assured him, that if he had formerly been directed to solitude, he was now summoned to court, and that if he would take charge of her conscience, she would be answerable for having chosen him to do so. And he consented, on condition that he should be required to attend her only when called by the duties of his office. This was in 1492.