The face of the hyperpituitary is striking and pretty sharply defined. It is long and narrow, with a tendency to prominence of the bony parts. Square, protruding jaw, high, thin, straight nose, emphasized eyebrows, and marked cheek-bones, comprise the leading points in its composition. On the other hand, the subpituitary is more rounded and trends toward the full moon effect, the chin recedes, the cheek-bones are buried under fat, the nose spreads more and is flatter. In its general expression, there is a complacence and tranquillity which is often mistaken for sleepiness, and often actually is dullness. The eunuchoid face is usually fat with puffy eyelids. The skin is smooth and cool, marble-like often, poor in pigment and color. Sometimes it is sallow, wrinkled and senile in a man in his early twenties. At others, it is distinctly feminine in its hairlessness, and the delicate texture of the skin, as well as in the clean-cut patterning of the features. Every gradient between premature senility and sex inversion is encountered. The thymic face frequently stamps its possessor at sight. Its owner has a smooth, soft skin, with little or no hair, and a dead white or "peaches-and-cream" complexion. One wonders, when unacquainted with the type, who the man's barber is, or where he learned to shave himself so well. It may be curiously velvety to the touch and swept by a faint sheen. Among children occur the most exquisite samples of the kind designated as the angelic child. The face is finely moulded and beautifully proportioned, features artistically chiselled, eyes blue or brown with long lashes, cheeks transparent with rapid, fleeting variations in coloring, thin lips, and oval chin. In the adult, the chin is receding, and the mouth seems underdeveloped in one variety. THE TEETH As closely connected with the internal secretions as are the bones of the face and the skull are the teeth. Tooth formation is essentially a modified bone formation. And as the bones of the face are influenced, so are the teeth influenced. But as each tooth is a miniature organ, inspectable by the eye as a unit, the action of the ductless glands is more obviously reflected for the observer to read. By their teeth shall ye know them. Upon the whole history of the evolution of each tooth, in the growth of the dental follicle and its walls, the fruition of the dentinal germ, the making of the enamel organ, the dental pulp, the cementum and the peridental membrane, the endocrines leave their mark.