There is a curious variation among the different internal secretion types in the reaction of the skin to stroking. When the skin, especially the skin over the shoulders, the breasts and the abdomen, is stroked with some blunt object, the blood vessels react either by a greater filling up or emptying of themselves. The latter occurs most regularly in the subadrenal types, the former in the hyperthyroid. Both forms of reaction run parallel to the different check or drive effects of the vegetative apparatus. With too much drive, that is, too much thyroid, there is the flushing reaction; with too little check, that is, with too little adrenal, there is the whitening. These differences probably explain the emotional reactions of the face. In anger, for example, some people become a dead white, others a fiery red. Whether one will do one or the other may depend upon the relative predominance of the thyroid or of adrenal in the individual. In the distribution of fat beneath and throughout the skin all of the endocrine glands appear to have a voice. The typically hyperthyroid and hyperpituitary individuals tend to be thin, as well also as those who have well-functioning or excessively functional interstitial cells. In all of these the administration of the respective internal secretions increases the burning up of material in the body, and all of them have a higher rate of tissue combustion than their confreres, with a subthyroid or subpituitary keynote in their cell chemistry, or with insufficient interstitial cell action. Generally the latter have a very dry skin, the former a moist skin. With delayed involution of the pineal, obesity results.