In females, the primary stimulus, the initial spark of femininity, must originate in the ovary. There are other forms of precocity in the female, dependent upon stimulations of other glands, but these forms are masculinisms, a masculinization of the personality, and not a true awakening of the feminine constitution. So one must distinguish sharply between a precocity by masculinization and precocity of premature feminization. The latter always implies the touch of the fairy's wand upon the sleeping ovaries. Sexual precocity in boys may be produced by a premature overactivity not only of the specific reproductive organs: the testes, but also by an early excess of secretion on the part of the cortex of the adrenal gland or the pituitary gland, or by a too early involution of the pineal or thymus. When such abnormalities of adrenal, pituitary, thymus or pineal occur in girls, it is the masculine streak in the hastening of growth that is made manifest. All this emphasizes the relative bisexuality of every normal, no matter how pronounced, when superficially viewed, his or her form of predominating sex may be. Under the right conditions recession of the most marked virility or femininity becomes conceivable, and occurs. THE SECRET OF THE MASCULINE Masculinization having entered upon the scene, one may well ask: what truly (which means chemically) lies behind all these differences and divergences between male and female? What is the secret of the variable internal secretion admixtures? You can tell us that the recipes are different, the ingredients different, the results different as a Nesselrode pudding is from, say, a rice pudding. But what is the inner mechanism of the process? Since the masculine and the feminine are but expressions of certain relative capacities and potentialities, some single principle must run through the making of both. Recognizing of course the qualifications inherent in so broad a statement the answer is: the handling of the lime salts. Life originated, or at least lived and worked for long ages in sea water. During these eras the salts of the sea have come to play a dominant rôle in its being. The lime salts, because of their peculiar properties of dissolving or precipitating themselves according to electrical conditions in their medium, have come to occupy a central position in all the processes of growth, metabolism and sex differentiation. So it is that masculinity may be described as a stable, constant state in the organism of lime salts, and the feminine as an unstable, variable state of lime salts. The male skeleton contrasts with the female as the stronger, larger, heavier and straighter because it is an expression of a greater capacity to utilize, store and keep lime in the system. Women throughout their reproductive period are liable to rapid and pendulum-like fluctuations of their lime content.