We should expect to find extraordinarily well-developed ante-pituitary action among eminent philosophers and men of science, and we do. Adequate action of it is present throughout the range of normals who evidence sufficiently ripened judgment as they progress through life. The ability to profit by experience, and to make more and more accurate judgments as one grows older implies at least a maximum efficiency of it. This maturation is not at all universal. Even after middle age, after forty and fifty years of reasoning, some individuals retain the juvenile mind of their youth. Like the Bourbons, they have learned nothing and forgotten nothing. Their ante-pituitary insufficiency often coupled with a post-pituitary excess, and other instabilities and disequilibriums in the endocrine system, render them immature morons, compared with what might be expected of them for their years. They are the people who are old enough to know better. For the same reasons, inhibition and emotional control are poor in them. Besides the ante-pituitary, in the evolution of judgment, and the judgment faculty, due stress must be laid upon the influence of the internal secretion of the testes or ovaries, the product of the interstitial cells. Although the probability is that the effects are indirect, through a stimulation of the ante-pituitary, the fact remains that, in a child, memory may be marvelous and judgment poor (such memory is possibly purely thyroid in its determination). With the advent of the gonads upon the scene, judgments become the centre of the play's plot undoubtedly. The intelligence of eunuchs and eunuchoids is in general low. The skull and brain of castrates, animal and human, is smaller than the average. Gall, the physiologist who popularized ideas concerning the meaning of the protuberances and depressions of the head in relation to faculty and character, early in the nineteenth century, was the first to prove this. Among historic castrates, eunuchs, not a single example of great intellect, of the creative type, is known. On the contrary, the native gifts of the mind were destroyed. Thus Abelard, who was punished with castration by his uncle for his love affair with Helöise, never composed a verse of poetry thereafter. IMAGINATION AS AN ENDOCRINE GIFT That brings us to the consideration of imagination as influenced by the endocrines. The physical conditions of exercise of the imaginative faculty have not been sufficiently investigated. Alcohol has long been known to act as an evocant of strange images. The hallucinations of delirium tremens are the results obtained in extreme intoxication. A strangely imaged flow of consciousness, the imaginative state, may also be evoked by morphine and cannabis indica. There is no doubt that the brain cells may be made to combine in the fresh, novel, and unfamiliar associations that are recognized as unreal.