What other hints have we that in spite of his fatigue disease he was a pituitocentric? The record of his physique and physiognomy, documentary and that left in portraits and photographs. He was tall and thin and his frame was naturally strong and large. Face was ruddy, and his grey eyes looked out from under deep overhanging brows and bushy eyebrows. The ears were large and prominent, the hair straight, the nose broad and well developed. All these are distinctive pituitary traits. The photograph of him taken by Maull and Fox in 1854 shows his chin to be the square firm kind that goes with the ante-pituitary type physique. (This photo is the frontispiece of the collection of essays entitled "Darwinism and Modern Science," edited by A.C. Seward and published in 1909). Charles Darwin, we may say, then, lived the life of one with a hyperfunctioning pituitary, the anterior portion dominating the posterior, a thyroid excess, and an adrenal much deficient, the combination settling the fate of a grand intellect in an invalid. It is interesting to note that an extant portrait of Erasmus Darwin, Darwin's distinguished grandfather, shows a pituitocentric, but with a rounder head and a fatter face, which point to a predominance of the post-pituitary over the ante-pituitary. Correspondingly, he was more speculative and poetic intellectually than his grandson, and more irascible and imperious in his moods. After 1872, when Charles Darwin was sixty-three years old, a marked change for the better occurred in his health. For the last ten years of his life the condition of his health was a cause of satisfaction and hope to his family. "He was able to work more steadily with less fatigue and distress afterwards." This is probably to be explained as following the gonadopause hi him--the cessation of activity of the interstitial cells. After this event, the adrenals in the male nearly always function more efficiently, and well being is improved even though the blood pressure often rises coincidently. In the relative vigor of that decade we have another bit of evidence that the adrenals had much to say over Darwin's life. EPILEPTIC GENIUS He had a fever when he was in Spain And, when the fit was on him, I did mark How he did shake: 'tis true, this god did shake His coward lips did from their color fly; And that same eye whose bend doth awe the world, Did lose his lustre: I did hear him groan. --Julius Caesar.