The knowledge that the shape and action of a man's body as well as his mind depend on the internal secretions inspires the hope of the emergence of a hitherto inconceivable controlling power over human life in the future. For in the wake of chemical discovery there has always come chemical control. The nature of chemical research, the necessity for clear thinking, accurate measurement, and experience in the actual handling of materials, the fundamental tradition and technique of the science, have made and will make the practical applications about which we today may only speculate. What the study of the internal secretions suffers from, at the beginning of the third decade of the twentieth century, is insufficient appreciation of its meaning for mankind. It is true that there are thousands of workers scattered throughout the world contributing their mites to the general store. They increase yearly, almost daily, and their achievements, in spite of an uncritical enthusiasm in some quarters and a semi-charlatanism in others, have been and continue magnificent. But they are pecking at a mountain which requires organized, massive, engineering organization for its blasting. The crying need is for an international institute, endowed and equipped for investigation upon the proper scale, with all the available appliances and methods already worked out and at hand. Such an institution would possess the right chemical laboratories for the making of blood analyses, metabolism examinations, and tests of endocrine functions. There would be X-ray machines and experts to radiograph the pituitary, pineal and thymus glands when possible. There would be psychologists to carry out intelligence tests, determine emotional reactions, and group mental aberrations, deficiencies and defectives. There would be statisticians, trained in biometrics, to criticize and compare data obtained. There would be anthropoligists to note and measure variations in angles and curves, ratios and quotients of the external conformation of the body. Internists would record the history and status of the organs and viscera. There would be librarians to collect, abstract and collate the vast, accumulating literature. In short, the mystery of personality, the most marvelous, complex, and variable process in the universe, would be attacked and at length penetrated systematically and persistently, with the ideal of absolute control of its composition as the goal in view.