The end came when he was literally in his prime. Only forty-two years of age, he might reasonably have looked forward to many years of active work and the enjoyment of his honors! But Lorenzo, although not a vicious, was a pleasure-loving man, and he had drained the cup of enjoyment to the very lees. His constitution was undermined by worry and late vigils, by the very intensity of interest wherewith he had devoted himself to the pleasures of the moment. Accordingly, late in 1491 he began to feel the gout, from which he had suffered for some years, becoming so troublesome that he was unable for the duties devolving on him. He had lost his wife, Clarice Orsini, in July, 1487, at a time when he was absent at the sulphur baths of Filetta, striving to obtain relief from pain; therefore his last years were lonely indeed. Life had lost its relish to the dying Magnifico. The only thing over which he showed a flash of the old interest was in March, 1492, when his son Giovanni (afterward Leo X), on being made a cardinal by Innocent VIII, was invested with the _insignia_ in the Abbey Church of Fiesole. Although then within a month of his end, although, moreover, so weak that he was unable to attend the investiture mass or to head his table at the banquet which followed, he caused himself to be carried in a litter into the hall, where he publicly paid reverence to his son as a prince of the Church. He then embraced him as a father and gave him his paternal blessing. That done, and after addressing a few words of welcome to his guests collectively, he was slowly borne back to his chamber to die. Nevermore was he seen in public. His ruling passion was, however, strong in death. In place of surrounding himself with clergy, his last hours were spent with the humanists and scholars he had loved so well. To his beautiful villa of Careggi, and to that room facing the south which he called his own, he retired, and summoned Ficino, Poliziano, and Pico della Mirandola to bear him company until he dipped his feet in the River of Death. They discussed many things, but principally the consolations afforded by philosophy. Then they reverted to the subject of the classics, and to the valuable codices which Lascaris was bringing back from Greece. But hope at last burned low, and the physicians had to confess that the case was beyond their skill. How rudimentary as regards medical science that skill was may be judged from the fact that the staple remedy prescribed by the great Milanese doctor, Lazaro da Ficino, who had been called in to consult with Lorenzo's own medical man, Pier Leoni of Spoleto, was a potion compounded of crushed pearls and jewels. As might have been expected, such a treatment accelerated rather than retarded the disease.