I now enter upon that portion of your Excellency's instructions which has reference to the epidemic of small-pox in the Saskatchewan. It is about fifty years since the first great epidemic of small pox swept over the regions of the Missouri and the Saskatchewan, committing great ravages among the tribes of Sioux, Gros-Ventres, and Flatheads upon American territory; and among the Crees and Assineboines of the British. The Blackfeet Indians escaped that epidemic, while, on the other hand, the Assineboines, or Stonies of the Qu'Appelle Plains, were almost entirely destroyed. Since that-period the disease appears to have visited some of the tribes at intervals of greater or less duration; but until this and the previous year its ravages were confined to certain localities and did not extend universally throughout the country. During the summer and early winter of '69 and '70 reports reached the Saskatchewan of the prevalence of small-pox of a very malignant type among the South Peagin Indians, a branch of the great Blackfeet nation. It was hoped, however, that the disease would be confined to the Missouri River, and the Crees who, as usual, were at war with their traditional enemies, were warned by Missionaries and others that the prosecution of their predatory expeditions into the Blackfeet country would in all probability carry the infection into the North Saskatchewan. From the South Peagin tribes, on the head-waters of the Missouri, the disease spread rapidly through the kindred tribes of Blood, Blackfeet, and Lucee Indians, all which new tribes have their hunting-grounds north of the boundary-line. Unfortunately for the Crees, they failed to listen to the advice of those persons who had recommended a suspension of hostilities. With the opening of spring the war-parties commenced their raids; a band of seventeen Crees penetrated, in the month of April, into the Blackfeet country, and coming upon a deserted camp of their enemies in which a tent was still standing, they proceeded to ransack it, This tent contained the dead bodies of some Blackfeet, and although these bodies presented a very revolting spectacle, being in an advanced stage of decomposition, they were nevertheless-subjected to the usual process of mutilation, the scalps and clothing being also carried away.