or eighth day to the internal inflammation, they had still some strength in them. But if they passed this stage, and the disease descended further into the bowels, inducing a violent ulceration there accompanied by severe diarrhoea, this brought on a weakness which was generally fatal. For the disorder first settled in the head, ran its course from thence through the whole of the body, and, even where it did not prove mortal, it still left its mark on the extremities; ... some, too, escaped with the loss of their eyes.... Some died in neglect, others in the midst of every attention. No remedy was found that could be used as a specific; for what did good in one case, did harm in another.... Such was the nature of the calamity, and heavily did it weigh on the Athenians; death raging within the city and devastation without. (Translation of Richard Crawley; Dent & Sons, London.) _Athens Ceases to be the Centre of Medical Learning._--It is safe to assume that one by one the more prominent of the physicians who had survived the events which have just been narrated, must have left Athens and taken up their abode in the various cities of Asia Minor and the neighboring islands, in Sicily, in Italy, etc. Hippocrates, who was thirty years old at the time when the plague broke out in Athens, appears not to have witnessed it. He practiced his profession and taught medicine in his native city; then he spent a certain number of years in traveling about as a peripatetic physician; and finally settled for the remainder of his life in Thessaly. But the length of each of these periods of his professional life is not mentioned by any of the authorities. About forty years after the death of Hippocrates, Alexander the Great had already nearly completed his series of brilliant conquests, and was taking steps to found a city, or rather, a university, in which medicine was to take an organized shape as one of the great departments of human learning. It may be well at this point, however, to interrupt this narrative of the regular course of events for the purpose of considering very briefly how far the physicians of that period had advanced toward gaining a permanent and honorable position in their respective communities.