"A son of Thomas Stinchcomb, of Woodford, near Berkeley, was infected with the natural smallpox at Bristol, and came home to his father's cottage. Four days after the eruptions had appeared upon the boy, the family (none of which had ever had the smallpox), consisting of the father, mother, and five children, was inoculated with vaccine virus. On the arm of the mother it failed to produce the least effect, and she, of course, had the smallpox, [Footnote: Under similar circumstances I think it would be advisable to insert the matter into each arm, which would be more likely to insure the success of the operation.--E. J.] but the rest of the family had the cow-pox in the usual way, and were not affected with the smallpox, although they were in the same room, and the children slept in the same bed with their brother who was confined to it with the natural smallpox; and subsequently with their mother. "I attended this family with my brother, Mr. H. Jenner." The following cases are of too singular a nature to remain unnoticed. Miss R--, a young lady about five years old, was seized on the evening of the eighth day after inoculation with vaccine virus, with such symptoms as commonly denote the accession of violent fever. Her throat was also a little sore, and there were some uneasy sensations about the muscles of the neck. The day following a rash was perceptible on her face and neck, so much resembling the efflorescence of the scarlatina anginosa that I was induced to ask whether Miss R--had been exposed to the contagion of that disease. An answer in the affirmative, and the rapid spreading of the redness over the skin, at once relieved me from much anxiety respecting the nature of the malady, which went through its course in the ordinary way, but not without symptoms which were alarming both to myself and Mr. Lyford, who attended with me. There was no apparent deviation in the ordinary progress of the pustule to a state of maturity from what we see in general; yet there was a total suspension of the areola or florid discolouration around it, until the scarlatina had retired from the constitution. As soon as the patient was freed from this disease this appearance advanced in the usual way. [Footnote: I witnessed a similar fact in a case of measles. The pustule from the cow-pock virus advanced to maturity, while the measles existed in the constitution, but no EFFLORESCENCE appeared around it until the measles had ceased to exert its influence.]