The whole question of medical practice depends on the answer we give to this question, and therefore one might go on indefinitely with its discussion. Neither the Editors' space and patience nor my time allow of this; but I should like to ask M.D., with all respect, if he remembers what Dr King Chambers said of the starvation that comes of over-repletion? Dr King Chambers occupied one of the most prominent places as a consultant in London (very probably, I suppose) when M.D. was a very young man. My late lamented friend, Dr Dewey of Meadville, Pennsylvania, used the phrase "starvation from over-feeding," not knowing that Dr King Chambers had used practically the same expression before him. That I made the same discovery myself, and independently, is not, I take it, a sign of acuteness of intellect or of observation. The amazing thing is that every practitioner is not compelled to make the same discovery. But if it is a true discovery, then it follows that all the signs of lowered vitality referred to by M.D., while they _may_ be caused by under-feeding, may also be caused by over-feeding and may therefore require for proper treatment, not increase of the diet, but diminution of it. A low temperature, therefore, a slow pulse, languor, pallor, inanition, fatigue, good-for-nothingness, inefficiency, anorexia, anaemia, neurasthenia, etc., etc., may all be due to blocking of the body with too much food as well as to supplying it with too little. Fires may be put out by heaping up too much coal on them. To make them burn briskly we ought to push the poker in and gently lift the coal so as to admit of the entrance of air. Then in a while our fire will become brisk and bright. And so it may be in the body. Nay, my opinion is that almost always these marks of depression are caused by blocking up of the body and that therefore the proper treatment is, as a rule, not increase but diminution of the diet. The place in the body in which the blocking first occurs is the connective tissues or the tissues that connect every part with every other. It is here that the lymph is secreted, and as the lymph joins the thoracic duct which conveys the products of digestion to the blood, it is obvious that lymph-secretion is a complementary digestive process and it is also obvious how blocking up of the connective tissues, which is the immediate cause of anorexia and inanition, usually comes to exist in the body.