The year of our Lord’s incarnation, 1348, had already come, when in the noble city of Florence, lovely beyond all others of Italy, appeared the mortal pestilence which by the operation of superior bodies, or from wicked deeds, was by the just judgment of God for our correction let loose on mortals. It began some years before in the eastern countries and after having deprived them of an inconceivable mass of living beings rolled westward in a continued course from realm to realm with mournful augmentation. Human wisdom and human prudence availed not, for the city had already been cleansed of its impurities by officers especially appointed; entrance was denied to all infected persons, and every means employed to preserve the public health. Neither were humble supplications to the Almighty more successful, although made not once but repeatedly in religious processions and divers other ways by devout persons; for very early in spring the dismal signs glared horribly palpable and manifested themselves in wonderful ways; not as in the east where bleeding at the nose was a plain symptom of inevitable death, but at the beginning, both in male and female, there appeared about the groins and under the arm-pits certain tumours some of which increased to the size of a common apple, others to that of an egg; and those greater and these less, and were vulgarly called _gavoccioli_. And from the two parts of the body above mentioned these deadly gavoccioli within a brief space began to sprout and swell indiscriminately in every other; and soon after this the nature of the disease began to change into black or livid spots, which in many appeared on the arms, thighs, and other places; some large and few, others small and numerous; and as the gavocciolo at first was and always remained a certain sign of death, so also were these spots on whomsoever they appeared. For the cure of this malady neither the advice of medical men nor the virtues of any nostrum availed or profited; on the contrary, whether it were that the nature of the illness would not permit, or that the ignorance of doctors (of whom, besides regular physicians, the number of both sexes without a particle of knowledge was enormous) could not divine the cause and therefore could apply no remedy; not only few survived, but almost all about the third day from the appearance of these symptoms, some sooner, some later, most of them without fever or any other accident, expired.