"If the simple or unprepared sap is mixed with the extract of tobacco, instead of the spices mentioned, it is rendered equally, perhaps more, active. Even the pure juice, unmixed and unprepared, appears to act with a force equal to that which has undergone the preparative process. Birds are very differently affected by this poison. Fowls have a peculiar capacity to resist its effects: a fowl died in twenty-four hours after the wound; others have recovered after being partially affected. "The eighteenth and succeeding experiments were made with the poison prepared from the chetik. Its operation is far more violent and rapid than that of the anchar, and it affects the animal system in a different manner. While the anchar operates chiefly on the stomach, alimentary canal, the respiration and circulation, the chetik is determined to the brain and nervous system: a relative comparison of the appearances on dissection, demonstrates in a striking manner the peculiar operation of each. A general view of the effects of the chetik on quadrupeds is given in these experiments. After the previous symptoms of faintness, drowsiness, and slight convulsions, it acts by a sudden impulse, which like a violent apoplexy prostrates at once the whole nervous system. In two of these experiments this sudden effect took place in the sixth minute after the wound, in another in the seventh minute: the animals suddenly started, fell down head foremost, and continued in convulsions until death ensued. This poison affects fowls in a much more violent manner than that of the anchar. They are first affected by a heat and itching of the breast and wings, which they shew by violently pecking those parts; this is followed by a loose discharge from the bowels, when they are seized with tremors and fluttering of the wings, which having continued a short time, they fall down head foremost, and continue convulsed till death. In some instances, particularly young fowls, the poison acts with great rapidity; death has frequently occurred within the space of a minute after a puncture with a poisoned dart. "Taken into the stomach of quadrupeds, the chetik acts as a most violent poison; but it requires about thrice the period to produce the same effect which a wound produces. But the stomach of fowls can resist its operation. Having mixed about double the quantity generally adhering to a dart with the food of a fowl, it consumed it without shewing any marks of indisposition. The poison of the anchar does by no means act as violently on quadrupeds as that of the chetik. I have given it to a dog: it produced at first nearly the same symptoms as a puncture; oppression of the head, twitchings, faintness, laborious respiration, violent contraction of the pectoral and abdominal muscles, &c. which continued nearly two hours; but after the complete evacuation of the stomach by vomiting, the animal gradually recovered.