Keep yourselves clean--body and raiment, and house and street.' The voice spoke, but no one heard. Then came the Plague again. Still no one heard the voice. It came again and again. It came in 1500, in 1525, in 1543, in 1563, in 1569, in 1574, in 1592, in 1603 (when 30,575 died), in 1625 (when 35,470 died), in 1635 (when 10,400 died), and lastly, in 1665. And in all that time no one understood that voice, and the City was never cleansed. All that was done was to light bonfires in the street in order to increase the circulation of the air. After the last, and worst attack, in 1666 the City was burned, and in the purification of the flames it emerged clean, and the Plague has never since appeared. The same voice speaks to mankind still in every visitation of every new pestilence. It used to cry aloud in time of Plague: it cries aloud now in time of typhoid, diphtheria, and cholera. Diseases spring from ignorance and from vice. Physicians cannot cure them: but they can learn their cause and they can prevent. The Plague of 1665 began in the autumn of the year before. It had been raging in Amsterdam and Hamburg in 1663. Precautions were taken to keep it out by stopping the importation of goods from these towns. But these proved ineffectual. Certain bales from Holland were landed and taken to a house in Long Acre, Drury Lane. Here they were opened by two Frenchmen, both of whom caught the disease and died. A third Frenchman who was seized in the same house was removed to Bearbinder Lane, St. Swithin's Lane, where he, too, died. And then the disease began to spread. A severe frost checked it for a time. But in March, when milder weather returned, it broke out again. The disease, when it seized upon a person, brought upon him a most distressing horror of mind. This was followed by fever and delirium. But the certain signs of the plague were spots, pustules, and swellings, which spread over the whole body. Death in most cases rapidly followed. Some there were who recovered, but the majority gave themselves over for lost on the first appearance. Many of the physicians ran away from the infected City: many of the parish clergy deserted their churches. The Lord Mayor and Aldermen, however, remained, by their presence giving heart to those of the clergy and physicians who stayed, and by their prudent measures preventing a vast amount of additional suffering which would otherwise have fallen upon the unhappy people. 51. THE TERROR OF THE PLAGUE. PART II.