New colours were presented to the regiment at Demerara on May 24th, 1841. In September and October of the same year a violent epidemic of yellow fever broke out in Demerara, and the mortality amongst the men of the 52nd Regiment was so alarming that that corps was moved to Berbice, and the entire duties of the garrison fell upon the 1st West India Regiment. The whole of the officers of the 52nd Regiment occupying the west wing of the Georgetown Barracks fell victims to this dreadful scourge, as did Captain French and Lieutenants de Winton and Archdale of the 1st West India Regiment. On the 11th of January, 1842, a detachment of the regiment, consisting of two lieutenants (Bingham and Wieburg), two sergeants and twenty-seven rank and file, left Georgetown, Demerara, by direction of the Under-Secretary of State for the Colonies (Lord John Russell), to proceed to Pirara, on the south-western frontier of British Guiana, and expel a party of Brazilians who had for some time encroached on British territory. The country through which the party had to pass was unexplored and almost unknown, and the duties were most arduous. It was intended to reach Pirara by ascending the Essequibo and Rypumani Rivers, and, to effect this, a particular description of boat, locally called _corials_, had to be built, each capable of holding eight men, including the Indians who paddled. During the journey seventy-three rapids or falls were crossed, in most instances the _corials_ being unladen and the stores carried above the falls; and it was not until February 12th that Lieutenant Bingham's party reached a point on the Rypumani, eleven miles from Pirara. Next day they took possession of the village of Pirara, which they found occupied by a detachment of Brazilian troops who had been quietly sent over the border. Having selected and fortified a position, and raised temporary shelter for his men, Lieutenant Bingham--as the Brazilian commander declined to withdraw--despatched Lieutenant Bush, 1st West India Regiment, who had accompanied the party as a volunteer, to Georgetown for further instructions. That officer arrived there on March 11th, and on April 19th he again started with a small reinforcement under Ensign Stewart. This second party reached Pirara on May 21st, and found the detachment all well, but half-starved, as the Brazilians refused to sell them anything, and the stores had been some time exhausted. However, on the arrival of the reinforcement the Brazilian troops considered it advisable to withdraw across the frontier; and, with the exception of a few occasional night forays made by half-breeds and Indians in the pay of the Brazilians, the detachment met with no further opposition.