Yet this did occur. When Charles V., the grandson of Ferdinand and Isabella, succeeded in 1519 to the throne of Spain, some of the Jewish exiles sent a deputation to him, requesting permission to reoccupy their ancient homes, free from the perpetual and pitiless interference of the Inquisition. In requital of this service, if he should be inclined to render it to them, they offered no less a sum than 800,000 crowns of gold. Charles received them favourably, and his council advised the acceptance of their offer. But Cardinal Ximenes, who had succeeded Torquemada as Inquisitor General, interfered, and sternly warned Charles that he could not comply with the request without unfaithfulness to Christ. Charles yielded, as his grandfather had yielded to Torquemada, and the petition of the Jews was rejected. Under the same influence he refused the Portuguese refugees permission to continue in Holland, whither many of them had fled. All who had not resided for six years in that country were obliged to quit it. In 1521 John III. succeeded Emmanuel as King of Portugal. The latter had promised the New Christians, on their consenting to receive baptism, that the Inquisition should not be introduced into Portugal.[169] But some of John’s advisers persuaded him that this promise was not binding, for two reasons—first, because the New Christians were notoriously unfaithful to their engagements; and secondly, because he had no power to make such an agreement without the consent of the Pope. To the Pope therefore John appealed for leave to set up the Holy Tribunal. But Clement VII. and his cardinals at once refused the petition, and ordered that all the New Christians whom John had arrested should be set at liberty. When, in 1534, Paul III. succeeded Clement, John renewed his petition. But Paul rejected it as resolutely as his predecessor had done, pointing out that Emmanuel’s promises ought in honour and good faith to be respected.